Preanalytical Variables and Alzheimer Disease Biomarker Concentrations in Cerebrospinal Fluid
نویسندگان
چکیده
منابع مشابه
Preanalytical variables and Alzheimer disease biomarker concentrations in cerebrospinal fluid.
Cerebrospinal fluid (CSF) -amyloid (A 1–42) is one of the key biological forms of -amyloid protein in brain tissue that inversely reflects brain amyloid burden with reduced concentrations in Alzheimer disease (AD) (1 ). Reductions in CSF A 1–42 have been shown to occur years before symptom onset (2 ) and to have good positive predictive value for progression from mild cognitive impairment to cl...
متن کاملImportance and impact of preanalytical variables on Alzheimer disease biomarker concentrations in cerebrospinal fluid.
BACKGROUND Analyses of cerebrospinal fluid (CSF) biomarkers (β-amyloid protein, total tau protein, and hyperphosphorylated tau protein) are part of the diagnostic criteria of Alzheimer disease. Different preanalytical sample procedures contribute to variability of CSF biomarker concentrations, hampering between-laboratory comparisons. The aim of this study was to explore the influence of fracti...
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BACKGROUND Carbonylation is an irreversible oxidative modification of proteins that has been linked to various conditions of oxidative stress, aging, physiological disorders, and disease. Increased oxidative stress is thus also considered to play a role in the pathogenesis of age-related neurodegenerative disorders such as Alzheimer disease (AD). In addition, it has recently become evident that...
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IMPORTANCE Individuals in the presymptomatic stage of Alzheimer disease (AD) are increasingly being targeted for AD secondary prevention trials. How early during the normal life span underlying AD pathologies begin to develop, their patterns of change over time, and their relationship with future cognitive decline remain to be determined. OBJECTIVE To characterize the within-person trajectori...
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BACKGROUND Definitive diagnosis of Alzheimer disease (AD) can be made only by histopathological examination of brain tissue, prompting the search for premortem disease biomarkers. We sought to determine if the novel brain injury biomarker, visinin-like protein 1 (VLP-1), is altered in the CSF of AD patients compared with controls, and to compare its values to the other well-studied CSF biomarke...
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ژورنال
عنوان ژورنال: Clinical Chemistry
سال: 2015
ISSN: 0009-9147,1530-8561
DOI: 10.1373/clinchem.2015.240069